Immune dysregulation / autoimmunity –  A potential connection with GPCR autoantibodies

GPCR autoantibodies have been reported in Long COVID and related conditions. We hypothesize that autoantibody-mediated interference with GPCR signaling could contribute to functional resistance to hormones that stimulate PGE2 production. Compensatory hormonal upregulation could then further increase PGE2 production, potentially creating another self-reinforcing loop.