{"id":4551,"date":"2026-08-21T18:29:12","date_gmt":"2026-08-21T18:29:12","guid":{"rendered":"https:\/\/pge2-hypothesis.com\/?page_id=4551"},"modified":"2026-08-23T18:04:36","modified_gmt":"2026-08-23T18:04:36","slug":"%e2%86%92-hormonal-multiresistance","status":"publish","type":"page","link":"https:\/\/pge2-hypothesis.com\/?page_id=4551","title":{"rendered":"\u2192 Hormonal multiresistance"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4551\" class=\"elementor elementor-4551\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c475911 e-flex e-con-boxed e-con e-parent\" data-id=\"c475911\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-17c2b32 e-con-full e-flex e-con e-child\" data-id=\"17c2b32\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8e7a17d elementor-widget elementor-widget-heading\" data-id=\"8e7a17d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Hormonal Multi-Resistance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-81b41e2 elementor-widget elementor-widget-text-editor\" data-id=\"81b41e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3><br \/>Hormonal multi-resistance &#8211; A potentially self-sustaining system<\/h3><p>Many hormones, cytokines and other signaling molecules stimulate PGE2 production. PGE2 can in turn modulate their production, secretion or signaling. We hypothesize that excessive PGE2 activity may impair the signaling of substances that normally stimulate PGE2, leading to compensatory upregulation and further PGE2 production.<\/p><p class=\"elementor-heading-title elementor-size-default\">\u2192 <a href=\"https:\/\/pge2-hypothesis.com\/?page_id=4711&amp;preview_id=4711&amp;preview_nonce=ea43e568e8&amp;preview=true\">PGE2 antagonizes other agents<\/a><\/p><p class=\"elementor-heading-title elementor-size-default\">\u2192 <a href=\"https:\/\/pge2-hypothesis.com\/?page_id=3441\">PGE2-mediated antagonism<\/a> and hormonal resistance, interrelated?<\/p><p class=\"elementor-heading-title elementor-size-default\">\u2192 A Hypothetical Model of <a href=\"https:\/\/pge2-hypothesis.com\/?page_id=1894\">&#8220;Hormonal multi-resistance&#8221;<\/a><\/p><p class=\"elementor-heading-title elementor-size-default\">\u2192 \u201cHormonal multi-resistance\u201d as a context-dependent <a href=\"https:\/\/pge2-hypothesis.com\/?page_id=3099\">survival mechanism?<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a77def6 e-con-full e-flex e-con e-child\" data-id=\"a77def6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3d07197 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"3d07197\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-scaled.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"Hormonal Multi-Resistance.figure\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6Mzk5NiwidXJsIjoiaHR0cHM6XC9cL3BnZTItaHlwb3RoZXNpcy5jb21cL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzA1XC9Ib3Jtb25hbC1NdWx0aS1SZXNpc3RhbmNlLmZpZ3VyZS1zY2FsZWQuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"726\" height=\"1024\" src=\"https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-726x1024.jpg\" class=\"attachment-large size-large wp-image-3996\" alt=\"\" srcset=\"https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-726x1024.jpg 726w, https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-213x300.jpg 213w, https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-768x1084.jpg 768w, https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-1088x1536.jpg 1088w, https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-1451x2048.jpg 1451w, https:\/\/pge2-hypothesis.com\/wp-content\/uploads\/2026\/05\/Hormonal-Multi-Resistance.figure-scaled.jpg 1814w\" sizes=\"(max-width: 726px) 100vw, 726px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8483d32 e-flex e-con-boxed e-con e-parent\" data-id=\"8483d32\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34e1439 elementor-widget elementor-widget-button\" data-id=\"34e1439\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Clarifiaction of proposed AVP, insulin and  leptin resistance-loops<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0e34a0b e-flex e-con-boxed e-con e-parent\" data-id=\"0e34a0b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7cdbc23 e-flex e-con-boxed e-con e-parent\" data-id=\"7cdbc23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hormonal Multi-Resistance Hormonal multi-resistance &#8211; A potentially self-sustaining system Many hormones, cytokines and other signaling molecules stimulate PGE2 production. PGE2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-4551","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=\/wp\/v2\/pages\/4551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4551"}],"version-history":[{"count":56,"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=\/wp\/v2\/pages\/4551\/revisions"}],"predecessor-version":[{"id":4973,"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=\/wp\/v2\/pages\/4551\/revisions\/4973"}],"wp:attachment":[{"href":"https:\/\/pge2-hypothesis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}